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Brenden Chen Selected Research

Hereditary Coproporphyria (Coproporphyrinogen Oxidase Deficiency)

11/2019International Porphyria Molecular Diagnostic Collaborative: an evidence-based database of verified pathogenic and benign variants for the porphyrias.
11/2019Recent advances on porphyria genetics: Inheritance, penetrance & molecular heterogeneity, including new modifying/causative genes.
11/2019Acute hepatic porphyrias: Identification of 46 hydroxymethylbilane synthase, 11 coproporphyrinogen oxidase, and 20 protoporphyrinogen oxidase novel mutations.

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Brenden Chen Research Topics

Disease

10Acute Intermittent Porphyria (Porphyria, Acute)
11/2019 - 05/2014
4Hepatic Porphyrias (Hepatic Porphyria)
11/2019 - 05/2014
3Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency)
11/2019 - 11/2019
3Hereditary Coproporphyria (Coproporphyrinogen Oxidase Deficiency)
11/2019 - 11/2019
3Porphyrias (Porphyria)
11/2019 - 11/2019
2Erythropoietic Porphyria (Congenital Erythropoietic Porphyria)
11/2019 - 11/2019
2Erythropoietic Protoporphyria
11/2019 - 11/2019
2Porphyria Cutanea Tarda
11/2019 - 11/2019
2Fabry Disease (Fabry's Disease)
01/2018 - 08/2017
1Hemochromatosis (Bronze Diabetes)
11/2019
1Infections
11/2019
1Hepatoerythropoietic Porphyria
11/2019
1Ataxia (Dyssynergia)
01/2019
1Stroke (Strokes)
01/2018
1Lysosomal Storage Diseases (Lysosomal Storage Disease)
01/2018
1Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
08/2017
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
08/2017
1Hyperplasia
06/2015
1Melanoma (Melanoma, Malignant)
01/2012
1Neoplasms (Cancer)
01/2012
1Carcinogenesis
07/2007

Drug/Important Bio-Agent (IBA)

8Heme (Haem)IBA
11/2019 - 05/2014
6Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)IBA
11/2019 - 11/2016
2AcidsIBA
11/2019 - 01/2019
2Adenosine Diphosphate (ADP)IBA
11/2019 - 11/2019
2IronIBA
11/2019 - 06/2015
2Coproporphyrinogen Oxidase (Coproporphyrinogen III Oxidases)IBA
11/2019 - 11/2019
2EnzymesIBA
11/2019 - 01/2018
2Protoporphyrinogen Oxidase (Protox)IBA
11/2019 - 11/2019
2GalactosidasesIBA
01/2018 - 08/2017
1Porphobilinogen Synthase (delta-Aminolevulinate Dehydratase)IBA
11/2019
1Aminolevulinic Acid (Levulan)FDA Link
11/2019
1Ferrochelatase (Heme Synthetase)IBA
11/2019
1Hydro-Lyases (Dehydratases)IBA
11/2019
1Uroporphyrinogen Decarboxylase (Uroporphyrinogen III Decarboxylase)IBA
11/2019
1Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)IBA
11/2019
1PorphobilinogenIBA
01/2019
1GadoliniumIBA
08/2017
1hydroxymethylbilaneIBA
06/2015
1Hemin (Panhematin)FDA Link
06/2015
1Acute Hepatic PorphyriaIBA
05/2014
1Proto-Oncogene Proteins B-rafIBA
01/2012
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2012
1Transcription Factors (Transcription Factor)IBA
07/2007
1Biological ProductsIBA
07/2007

Therapy/Procedure

1Liver Transplantation
06/2015
1Therapeutics
05/2014